Since a large proportion of missense variants showing almost no Na+ current and nonsense variants caused diverse neuronal disorders covering almost the whole spectrum mentioned above, it is difficult to establish a correlation between clinical severity and electrophysiological properties of SCN8A LOF variants as we did for SCN8A GOF variants,8 although it appears that episodic ataxia variants caused milder LOF effects than chronic ataxia variants as well as the biallelic SCN8A variants causing DEE. Here, SCN8A is linked to Familial paroxysmal ataxia.