The heparin-binding hemagglutinin (HBHA) is a protein related to Mtb dissemination by altering actin polymerization, this protein enables the colonization of pneumocytes and the posterior transcellular migration [20,21] and the mycobacterial kinase pknD, which is important in CNS infection through the adhesion to endothelial cells of the cerebral microvasculature, but is not necessary for pulmonary disease [22,23]. This evidence concerns the gene CTSK and lung disorder.