OCLN and neoplasm: In mice bearing HCT116 xenografts infected with F. nucleatum, the application of Br-J-I decreased tumor cell proliferation (as indicated by decreased Ki-67 content), tumor weight, inflammation in the microenvironment of CRC cells (decreased TNF-α and IL-1β) and increased expression of cell adhesion molecules (occludin and zonula occludin-1) [22].