The cGAS–STING pathway can recognize a variety of viruses, such as poxvirus (VACV), human papillomavirus (HPV), human cytomegalovirus (HCMV), adenovirus (Ad), herpes simplex virus (HSV-1), etc., and is activated early in infection to induce innate immune-initiated type I interferon activation, which can be eliminated in time to protect the body [38,39,40]. The gene discussed is CGAS; the disease is infection.