IL-4 also suppresses the production of inflammatory proteins like cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and pro-inflammatory chemokines, like IL-8, CCL2, CCL3, CCL4, and CCL5, which regulate immune cell recruitment to the infection site, thereby controlling immune cell trafficking and reducing excessive inflammation [100,101]. This evidence concerns the gene PTGS2 and infection.