Aβ (1-42) induced synaptic vulnerable neuronal cell’s protein such as secreted frizzled-related protein-1 (SFRP-1), T-tau, P-tau, β-catenin, TGF-β were increased two-fold in untreated SH-SY5Y neuroblastoma cells (Figure 7a,b). The gene discussed is TGFB1; the disease is neuroblastoma.