SLC39A8 and adenocarcinoma: There is evidence of the overexpression of Zrt-Irt-like protein 4 (Zip4) in pancreatic cancers allowing for Zn accumulation [16], whilst other studies reported a downregulation of Zip8 and Zip3 transporters in adenocarcinoma tissue sections accompanied by the loss of intracellular Zn during well-differentiated and progressing pancreatic malignancy [17].