Typically, CEP55 is expressed during embryogenesis and is silent in adult tissues except in the testis and thymus; however, the overexpression of CEP55 has been reported in multiple cancer types, including breast, non-small cell lung, prostate, and esophageal squamous cell carcinoma [12,13,14,15]. Here, CEP55 is linked to esophageal squamous cell carcinoma.