CD276 and hepatocellular carcinoma: Vobramitamab duocarmazine (MGC018), is an ADC consisting of a humanized anti-B7-H3 mAb tethered to a duocarmycin analogue [79] and is currently being tested in a phase I trial (NCT05293496) in combination with lorigerlimab (MGD019), a bispecific dual affinity re-targeting (DART) molecule [80] directed against PD-1 and CTLA-4, in relapsed or refractory solid tumors, including HCC.