Recently, Tian et al., aiming to overcome the variability in expression of GPC2 and B7-H3 on neuroblastoma cells, constructed a bicistronic CAR, which compared to classic single antigen CAR T-cells showed enhanced anti-tumor efficiency, longer T-cell endurance and resilience to exhaustion both in vitro and in vivo [188]. Here, CD276 is linked to neoplasm.