Furthermore, B7-H3+ lesions exhibited significantly lower CD8+T-cell intratumoral density compared to B7-H3− lesions (p = 0.0162) [92], while high B7-H3 expression was correlated with lower median number of CD8+T-cells in the tumor center, compared to low expression (86.4/mm2 vs. 157.7/mm2) [29]. This evidence concerns the gene CD276 and neoplasm.