In the latter study, shRNA-mediated B7-H3 silencing in the N87 gastric cancer cell line suppressed cell migration and invasion in vitro and in vivo; downregulated metastasis-associated CXCR4; and inhibited PI3K/AKT, MAPK/ERK, and JAK2/STAT3 phosphorylation [94]. The gene discussed is CD276; the disease is gastric cancer.