The induction of the Akt/PI3K signaling pathway is likely to trigger the pro-proliferative and migratory effects of CBS-synthesized H2S. These findings were validated in an in vivo model, where the growth rate in mice bearing xenografts of either HCT116 cells or patient-derived tumor tissue were significantly reduced following the silencing of CBS expression and/or inhibition of CBS expression via AOAA [176]. Here, CBS is linked to neoplasm.