IL1B and breast carcinoma: Other cytokines in the list of top downregulated genes were C-C motif chemokine ligand 20 (CCL20), C-X-C motif chemokine ligand 1 (CXCL1), as well as interleukin-1β (IL1B), which were also more than 2-fold downregulated by seemingly indirect mechanisms and which were reported to have diverse breast cancer-promoting properties [87,88,89,90].