CSF3 and breast cancer: We selected the top two downregulated cytokines from the RNA-seq data, namely granulocyte colony-stimulating factor (G-CSF or CSF3) and interleukin-6 (IL-6), both of which have been reported to support breast cancer growth in various ways [47,48,49,50,51,52], and confirmed their downregulation by RT-qPCR.