NLRP3 and metabolic disease: Another study demonstrated that the use of tilianin and syringin in this model not only ameliorated metabolic disorders and improved cardiac function in diabetic rats but also significantly increased the expression of TLR4, NF-Kb, NLRP3, IL-1β (85).In the STZ-induced C57BL/6 mouse model, it was observed that DCM was prevented in STZ-induced diabetic mice by inhibiting NF-κB and NLRP3 (86).