PTGS2 and intracerebral hemorrhage: reported elevated cyclooxygenase-2 (COX-2) expression in a mouse model of intracerebral hemorrhage (ICH) [35], and the administration of the antioxidant Fer-1 via in situ or intraventricular injection inhibited the generation of lipid peroxides and COX-2 in the perihematomal tissue of ICH, thereby minimizing secondary brain injury [35].