The GKN1 rs4254535 allele C significantly increased the prognosis of no family history patients of lung cancer (MST: 42.3 M; P = 0.0281), and adenocarcinoma (MST: 55.37 M; P = 0.008) patients, and effectively prolonged MST (Table 3). Here, GKN1 is linked to adenocarcinoma.