In addition to bioinformatics analysis, we constructed the si-RNAs of the 3 pyroptosis-related genes (CASP9, GSDME, IL1B) and OE-plasmid of the TIRAP in the model and transfected ccRCC 786-O and 769-P cells to verify their cellular functions. The gene discussed is IL1B; the disease is nonpapillary renal cell carcinoma.