In addition to bioinformatics analysis, we constructed the si-RNAs of the 3 pyroptosis-related genes (CASP9, GSDME, IL1B) and OE-plasmid of the TIRAP in the model and transfected ccRCC 786-O and 769-P cells to verify their cellular functions. This evidence concerns the gene GSDME and nonpapillary renal cell carcinoma.