Upregulation of Trop-2 has been associated to poor prognosis of pancreatic, gastric, ovarian, lung and colorectal cancers (Relli et al., 2018; Guerra et al., 2021), consistent with a role in tumor progression (Trerotola et al., 2013a; Trerotola et al., 2013b; Hsu et al., 2020; Trerotola et al., 2021). Here, TACSTD2 is linked to neoplasm.