ESR2 and malignant colon neoplasm: In this analysis of WoS, there were nine clusters for the keywords: “#0 acupuncture,” “#1 network pharmacology,” “#2 colon cancer,” “#3 colorectal cancer,” “#4 inflammatory bowel diseases,” “#5 usnic acid,” “#6 integrative medicine,” “#7 estrogen receptor beta,” “#8 neural regeneration.” The keyword “colorectal cancer” in the cluster “#3 colorectal cancer” first appeared in 2000 and had the highest frequency.