It has been discovered that IL-6 isrelated to the pathophysiology of ischemic cardiovascular events, such as unstable angina and ACS [11].Angiotensin II-mediated vasoconstriction, oxygen radical release, and endothelial dysfunction can be caused by IL-6-induced up-regulationof angiotensin II type 1 receptor gene expression. The gene discussed is IL6; the disease is angina unstable.