Thus, α-SMA can communicate with the nucleus to controlcollagen synthesis.72 Moreover, stimulationof HSCs is an essential phase in the progression of liver fibrosis.35 The activation of HSCs is crucial to the occurrenceof liver fibrosis.73 Elevation of α-SMAlevels acts as a phenotypic marker, indicating HSC phenotypic transitioninto myofibroblast-like cells. The gene discussed is ACTA1; the disease is Hepatic fibrosis.