CASS4 encodes a cell adhesion molecule important for axonal transport and has been implicated in APP (amyloid precursor protein) metabolism.40,41 Although CASS4 was identified as a susceptibility gene for clinically diagnosed AD dementia, our results are illuminating toward a mechanistic explanation by specifically suggesting a relationship between APOE and CASS4 on influencing amyloidosis. This evidence concerns the gene APP and amyloidosis.