Notably, immunofluorescent images showed that the expression of CD206 (a marker of M2 macrophage) rather than iNOS (a marker of M1 macrophage) had a significant increase in IPF patients compared with normal group (Figure 1D and S1C) and was positively correlated with SGK1 expression (Figure 1E). This evidence concerns the gene MRC1 and idiopathic pulmonary fibrosis.