SGK1 and idiopathic pulmonary fibrosis: We further conducted a mouse model of macrophage depletion mainly in the lung by intratracheal instillation with clodronate liposomes and continued to administrate with BLM and LPS (namely Clo+ BLM + LPS group, as described in Methods) to investigate whether the involvement of SGK1 in IPF was dependent on macrophage transformation.