Via this m6A-dependent mechanism, upregulation of CCAR1 (Cell Division Cycle And Apoptosis Regulator 1) 39, SMAD3 (Mothers against decapentaplegic homolog 3) 40, and SNAIL2 (Snail family transcriptional repressor 2) 41 by IGF2BP2 was demonstrated to promote metastatic responses of prostate, gastric, and head and neck cancer, respectively. This evidence concerns the gene SMAD3 and head and neck cancer.