GSK3B and diffuse large B-cell lymphoma: In summary, DLBCL-derived exosomes can be taken up by macrophages, and DLBCL-derived exosomal ENO2 accelerated glycolysis via GSK3β/β-catenin/c-Myc signaling pathway to regulate macrophages toward an immunosuppression phenotype, which could consequently promote DLBCL progression.