The protein levels of p-GSK3β (Ser9), β-catenin and c-Myc was detected in THP-1 macrophages stimulated by exosomes from different ENO2 stably transfected DLBCL cells to ascertain the impact of DLBCL-derived exosomal ENO2 on GSK3β/β-catenin/c-Myc signaling pathway. The gene discussed is GSK3B; the disease is diffuse large B-cell lymphoma.