β-catenin inhibitor ICG001 (5 μM) and activator SKL2001 (20 μM) were used to verify whether the regulation of macrophages polarization by DLBCL-derived exosomal ENO2 was mediated through GSK3β/β-catenin/c-Myc signals. Here, GSK3B is linked to diffuse large B-cell lymphoma.