THP-1 macrophages were subsequently exposed to exosomes derived from DLBCL cells for 24 h, and the levels of M2 macrophages markers (mRNA levels of IL-10 and TGF-β by qPCR, IL-10 concentration in supernatant by ELISA, CD68 and CD206 expression by flow cytometry) and M1 macrophages markers (mRNA levels of IL-12p40 and TNF-α by qPCR, IL-12p40 concentration in supernatant by ELISA) were detected. The gene discussed is TNF; the disease is diffuse large B-cell lymphoma.