Patient 2, a girl aged 4 years and 2 months from Xian province of China, presented with steroid resistant nephrotic syndrome (24-hour urine protein 110.68 mg/kg, serum albumin 18.5 g/l), microscopic hematuria, edema of face and limbs, hypertension (140-170 mmHg/100-120 mmHg), hyperspasmia, bilateral hydronephrosis of renal pelvis, enlarged liver and spleen, abdominal distension, vomiting, headache, reversible posterior encephalopathy syndrome and pneumonia. This evidence concerns the gene ALB and nephrotic syndrome.