Patient 2, a girl aged 4 years and 2 months from Xian province of China, presented with steroid resistant nephrotic syndrome (24-hour urine protein 110.68 mg/kg, serum albumin 18.5 g/l), microscopic hematuria, edema of face and limbs, hypertension (140-170 mmHg/100-120 mmHg), hyperspasmia, bilateral hydronephrosis of renal pelvis, enlarged liver and spleen, abdominal distension, vomiting, headache, reversible posterior encephalopathy syndrome and pneumonia. Here, ALB is linked to Posterior Leukoencephalopathy Syndrome.