All xenograft models were sacrificed on the 21st day and upon removal of tumors, images showed a significant reduction in the volume of tumor within the YTHDF3-/- groups compared to both the WT- group and OE-YTHDF3 group, indicating that the upregulation of YTHDF3 promoted tumorigenesis in vivo (P < 0.01) (Fig. 4B-C). The gene discussed is YTHDF3; the disease is neoplasm.