Further analyses focusing on the classical phenotype markers of macrophages revealed that IL4I1 exhibited a positive association with markers for M2 (TGFB1, IL10, CD163, and CSF1R), while displaying an inconsistent association with M1 markers (IL12A, NOS2, PTGS2, CCL3, and TNF) based on TCGA-GBM and CGGA cohort data (Figure 6C). This evidence concerns the gene TGFB1 and glioblastoma.