Firstly, despite the inclusion of data from human samples and in vitro experiments, further investigations necessitate the use of specific IL4I1CX3CR1KO mice models to delve deeper into the IL4I1-mediated downstream mechanism between M2-like macrophages and glioma, encompassing glioma progression and M2-like macrophage polarization. The gene discussed is IL4I1; the disease is central nervous system cancer.