Two other conditions referred to as familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS)—together with NOMID—are known collectively as cryopyrin-associated periodic syndromes (CAPS), the subserving mechanism of which is associated with disorders of inflammasomes and related interleukin (IL)-1 family cytokines due to mutations in the NLRP3 gene. The gene discussed is NLRP3; the disease is Muckle-Wells syndrome.