Given the wide variability of PASH syndrome’s genetic background, PG, and its syndromic form PASH may constitute a spectrum of polygenic autoinflammatory disorders, as supported by the overexpression of proinflammatory cytokines IL-1β, IL-17, and TNFα, in affected patients (137). Here, IL1B is linked to Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome.