TNF and autoimmune disease: After various inflammatory stimuli, including infection, injury, autoimmune diseases, and tumor-related inflammation, LRG1 may be produced in systemic or local tissues, including pro-inflammatory cytokines IL-6, TNF-α, and IL-1β may promote the production of LRG1 and directly participate in inflammatory diseases such as Lupus nephritis 20 and Rheumatoid arthritis 21.