During IMQ-induced psoriasiform dermatitis progression, LRG1-enriched EVs released from keratinocytes induce macrophage polarize to M1 by a TGFβR1-dependent pathway and subsequently up-regulates expression of some inflammatory genes, such as TNF-α, and IL-1β, thereby promoting psoriasiform dermatitis. The gene discussed is TNF; the disease is Psoriasiform dermatitis.