PTEN and glioblastoma: Moreover, correlation rank-based GSEA analysis showed that lineage plasticity-related pathways 46, 49-51, such as NE differentiation, glioblastoma (GB) plasticity, loss of PTEN, EZH2 signaling, and dual knockout of RB1 and TP53 up-regulated signaling (LNCaP_DKO_UP), as well as pathways implicated in proliferation and stemness, such as E2F targets, G2M checkpoint, and MYC signaling, were the most significantly activated pathways.