Moreover, correlation rank-based GSEA analysis showed that lineage plasticity-related pathways 46, 49-51, such as NE differentiation, glioblastoma (GB) plasticity, loss of PTEN, EZH2 signaling, and dual knockout of RB1 and TP53 up-regulated signaling (LNCaP_DKO_UP), as well as pathways implicated in proliferation and stemness, such as E2F targets, G2M checkpoint, and MYC signaling, were the most significantly activated pathways. This evidence concerns the gene EZH2 and glioblastoma.