Given that the CTLD domain is required for both functions of CD93 to promote tumor angiogenesis and induce CCL21 secretion from MCs and that pleural silencing of CCL21 did not altogether abolish the antitumor effects of M057 (Figure 6L), we assumed that M057 might also show anti-lung tumor efficacy by normalizing tumor vasculature. Here, CCL21 is linked to neoplasm.