In addition, the previous intrapleural injection of B16F10-EVs or EVs from murine 4T1 breast cancer cells from mice on a BALB/c background (4T1-EVs) inhibited the growth of LLC tumors (Figure S1E-F), indicating a tumor antigen- and MHC-independent inhibition of lung tumor growth. This evidence concerns the gene HLA-C and neoplasm.