EGFL7, SDSL, PPP1R13l, SMTNL2, MFAP4 and TAGLN were highly expressed in heart failure samples (Figures 2C–H), and the high expression of these 6 hub gene may promote the progression of heart failure and be a risk factor for heart failure patients, while SGPP2 was highly expressed in normal samples (Figure 2I), which may play a protective role for heart failure patients. The gene discussed is SGPP2; the disease is heart failure.