C- reactive protein, age, anemia (hemoglobin level <12 g/dl in women and <13 g/dl in men according to the World Health Organization definition15), HP, DM, dyslipidemia, CAD, chronic kidney disease, AF, obesity (BMI ≥ 25), cholinesterase level. The gene discussed is BCHE; the disease is obesity due to melanocortin 4 receptor deficiency.