The metal ion binding proteins such as annexin A1 (ANXA1), annexin A5 (ANXA5), protein S100A2 (S100A2), and protein S100A13 (S100A13) are at the peripheral edge of the protein network of MCF-7 breast cancer cells without zinc exposure (Supplementary Figure 9a) and again in the network of the differentially expressed proteins in MCF-7 with zinc exposure compared to MCF10A T120 (Supplementary Figure 9a). Here, S100A2 is linked to breast cancer.