PHGDH and Familial prostate cancer: Moreover, the reduction of metabolic enzymes including D-3-phosphoglycerate dehydrogenase, adenylosuccinate lyase, inosine-5′-monophosphate dehydrogenase, and translational elongation factor Tu under zinc exposure (Table 1) might be relevant to the decreased cell viability in MCF-7 breast cancer cells under zinc exposure [10], but the expression of these metabolic enzymes is not changed in PC3 prostate cancer cells.