Prohibitin (PHB) is prominent in the functional network of the differentially expressed proteins in the prostate cancer cells (PC3) with zinc exposure (Supplementary Figure 10b), apart from the heat shock proteins encoded by HSPD1, HSPA1B, and HSPB1. Heat shock protein 90 kDa α (cytosolic) class B member 1 isoform (HSP90AB1), proteasome subunit α type 1 (PSMA1), elongation factor γ (EEF1G), and 40S ribosomal protein SA (RPSA) are predominant in the protein network of the differentially expressed proteins in PC3 cells without zinc exposure (Supplementary Figure 10a). This evidence concerns the gene HSPD1 and Familial prostate cancer.