Recently, Vennin and colleagues reported that chemotherapeutics such as taxanes can trigger tumor cells eradicated by directly increase T cell cytotoxic activity without T cell receptors (TCR) activation both in murine and human models.[129] CD4+ and CD8+ T cells were isolated from mouse spleens and treated with docetaxel in vitro, subsequently, these treated T cells were co-cultured with organoids derived from tumor suppressor genes Brca1 and Trp53 (KB1P) models. This evidence concerns the gene CD4 and neoplasm.