The LGBM algorithm selected the 30 most crucial features from the entire set, which encompassed: sex type, age, BMI, CCI score, vaccination before having PCR test, COVID-19 medications, comorbidities including cardiovascular disease, COPD, renal disease, depression or anxiety, long-term medication such as NSAID, drugs for hypertension, drugs for GORD, aspirin, statin, antihyperuricemic, laboratory test results contain AST (GOT), ALT (GPT), creatinine, RBC, hemoglobin, MCH. The gene discussed is GPT; the disease is depressive symptom measurement.