PTGS2 and Alzheimer disease: The active ingredients of the above 6 TCMs are mainly involved in the regulation of prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide Synthase 2 (PT GS2), retinoid X receptor, alpha (RXRA), cholinergic receptor and other genes such as muscarinic 1 (CHRM1), nitric oxide synthases 2 (NOS2), estrogen receptor 1 (ESR1), which may be a potential drug to interfere with the pathological development of AD (Figure 7B).