Current research explores the influence of seizure activity on tau levels in brain, CSF, and blood, proposing that epilepsy is a tauopathy like AD and CTE – with proposed mechanisms of tau deposition including production during ictal and interictal activity, axonal sprouting and formation of aberrant connections in response to injury, cell death, physical injury during seizures, and decreased clearance (94). Here, MAPT is linked to tauopathy.