In contrast, intracranial lesions are more common in MOG-AD patients and typically present as diffuse, fluffy, and poorly demarcated white matter lesions, which can be present in cortical gray matter, subcortical white matter, deep white matter, brainstem, basal ganglia, thalamus, and cerebellum, with contrast enhancement (17, 24–27). The gene discussed is MOG; the disease is Alzheimer disease.