In cultured human neuroblastoma cells (NLF cell line), overexpression of ATP13A2 results in cellular protection against high concentrations of Mn compared to mutated forms of ATP13A2 (c.546C > A/p.Phe182Leu, c.1510G > C/p.Gly504Arg and c.1537G > A/p.Asp513Asn) (12). This evidence concerns the gene ATP13A2 and neuroblastoma.