Lumican is a non-collagenous extracellular matrix protein that belongs to class II of the short leucine-rich proteoglycan family (SLRPs).35,36 Lumican is overexpressed in a variety of cancers, and it is thought to be responsible for promoting cancer cell migration, invasion, and proliferation, while its downregulation is important in reducing cancer cell migration and invasion.37,38 The novel quinoline derivative (compound 91b1) developed by Yuan Zhou demonstrated antitumor efficacy in nude mice via downregulation of lumican. Here, LUM is linked to cancer.