Flasbeck and Brüne (2021) confirmed that FKBP5 methylation, which regulates GR sensitivity, is associated with psychopathology but not with the severity of childhood adversity, suggesting that the regulatory role of the FKBP5 gene in the interplay between ELS and depression remains ambiguous and requires further investigation in larger samples. The gene discussed is NR3C1; the disease is depressive disorder.