Palma-Gudiel et al. assessed 48 pairs of monozygotic twins (n = 96 subjects) with a history of lifetime anxiety and depressive disorders, and DNA extracted from peripheral blood was analyzed for epigenetic changes, revealing that NR3C1 promoter exon 1D becomes a suggestive novel target for stress-related disorders sensitive to early adversity-related epigenetic changes (Palma-Gudiel et al., 2018). Here, NR3C1 is linked to depressive disorder.