FLCN and Birt-Hogg-Dube syndrome: Therefore, in the absence of FLCN, as in BHD patients, TFEB is negatively regulated since non-phosphorylated; hence, it translocates to the nucleus to induce the transcriptional programs promoting autophagy and, also, to further promote mTORC1 activity through a negative feedback loop that relies on transcriptional induction of RagC/D GTPases (Napolitano et al., 2020).