Recently, Rey et al. (2021) first reported that the overexpression of SNCA-AS in SH-SY5Y cells increased the expression of SNCA and the production of α-Syn; then, by RNA-sequencing analysis they investigated the molecular pathways related to both SNCA-AS and SNCA overexpression, focusing on DA-ergic and GABA-ergic synapses, for their relevance in PD and senescence. Here, SNCA is linked to Parkinson disease.