CREB1 and Parkinson disease: In this respect, Feng et al. (2020) revealed that the circDLGAP4/miR-134-5p pathway affects both the cAMP response element binding protein (CREB) and its downstream targets like BDNF, PCG-α (Feng et al., 2020), suggesting a neuroprotective circDLGAP4/miR-134-5p/CREB pathway in PD pathogenesis.