INS and Parkinson disease: Hence, Kumar and co-workers suggested that circZip-2 may be protective against PD sponging the miR-60 and that the loss of circZip-2 enhanced the miR-60 activity causing the downregulation of PD protective genes in turn; conversely, in case of Zip-2 silencing, insulin signaling via daf-16 pathway restored PD protective activity (Kumar et al., 2018).