AGO2 and nervous system disorder: Interestingly, the silencing of ciRS-7 can occur through the recruitment of Argonaute 2 (Ago2) protein and the interaction between ciRS-7 and miR-651-5p (Hansen et al., 2011), a ncRNA downregulated in PD patients with several targets in the brain related to neurological disease, included SNCA (Uwatoko et al., 2019).