FH and Alzheimer disease: Another study revealed that HSV-1 infection of human neuronal glial cells induced miRNA-146a, which targets key components of the arachidonic acid pathway and fumarate hydratase (FH), enabling HSV-1 to evade the complement system, exacerbating neuropathological changes in AD (Hill et al., 2009; Zhao and Lukiw, 2018a; Slota and Booth, 2019).