In another study, Nishimura and colleagues compared the neuroblastoma chemopreventive potential of eight different chalcones[56]; while all chalcones displayed significant cytotoxicity against neuroblastoma cells, the lead compound isobavachalcone was safe for normal cells even at high concentrations, but induced caspase-3/9-dependent apoptosis in neuroblastoma cells. The gene discussed is CASP3; the disease is neuroblastoma.