Mechanistically, butein is known to: (i) regulate BCL2/Bax ratio, induce caspase activity, and consequently drive apoptosis; (ii) stimulate DR5 and mediate caspase-3-dependent apoptosis in TRAIL-resistant cells; and (iii) inhibit NFκB and dictate NFκB-mediated CXCR4-dependent tumor cell migration. The gene discussed is CASP3; the disease is neoplasm.