No significant differences observed in CD4+ cells, but co-infection patients had lower levels of CD8+ T cells (54.49 [22.28–77.60] vs. 158.17 [67.10–321.33], p = 0.008), and higher CD4/CD8 ratio (3.76 [2.73–5.41] vs. 1.51 [1.19–2.75], p = 0.004) than that of ICU-acquired infection patients. Here, CD4 is linked to coinfection.