Cell death mechanisms in either regulated biological processes or cancer therapy seem to commonly involve targeting and compromising membrane integrity: mitochondrial channel formation from Bax oligomer in apoptosis (Bogner et al., 2010), MLKL pores formed on cell surfaces and nuclear membranes in necroptosis, or perforin pores inserted onto plasma membrane of targeted cells (Liu and Lieberman, 2020). This evidence concerns the gene PRF1 and cancer.