ATP7B and chronic kidney disease: In summary, four genes (SLC34A2, TRPV6, FCGR2A, and ATP1A3) were upregulated under high adenine diet-induced CKD (Figure 5D), while 10 genes (SLC5A1, SLC34A1, VDR, SLC34A3, SLC30A1, ATP7B, SLC6A19, SLC9A3, ATP2B2, and S100G) were downregulated (Figure 5E).