In the amyloid precursor protein swedish mutation/presenilin deletion mutation 9 (APPswe/PSΔE9) double transgenic AD model study, the levels of peroxisome proliferator-activated receptor-gamma (PPARγ) co-activator-1alpha (PGC-1α)/PPARγ level were decreased (Chen et al., 2023). This evidence concerns the gene PPARG and Alzheimer disease.